BCL-2 proteins in senescence: beyond a simple target for senolysis? - CRCL-Mitochondries, caspases et mort cellulaire Access content directly
Journal Articles Nature Reviews Molecular Cell Biology Year : 2023

BCL-2 proteins in senescence: beyond a simple target for senolysis?

Abstract

BCL-2 and related proteins are major regulators of apoptosis that have emerged as promising targets for the elimination senescent cells (or ‘senolysis’) to improve age-related diseases and promote healthy ageing. However, seminal observations and recent findings shed light on non-apoptotic roles of BCL-2 proteins in the regulation of cellular senescence.
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Dates and versions

hal-04182726 , version 1 (21-08-2023)

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Nadine Martin, Nikolay Popgeorgiev, Gabriel Ichim, David Bernard. BCL-2 proteins in senescence: beyond a simple target for senolysis?. Nature Reviews Molecular Cell Biology, 2023, 24 (8), pp.517-518. ⟨10.1038/s41580-023-00594-y⟩. ⟨hal-04182726⟩
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