Abstract : Whatever the challenge is for a rational observer, European regions and Regionalism have become common concerns in Europe for the last thirty years in the realm of European Union, not to speak of centuries in some European states. Sustainable development is another controversial notion although it is largely used and has been introduced since the late eighties in European glossary. In the line of the Caenti Alba Iulia conference program, the aim of this communication is to relate together those two concepts -region and sustainable development- with that of territorial intelligence. In a world that continuously witnesses the disasters of state imperialism and aggressive competition, territorial intelligence dictates that regions should not behave and/or be considered as mini-states, i.e. territorial or sociocultural entities that establish their legitimacy on zero sum antagonisms. It is our view that the permanence of regions in the history and around the world is a proof that (a) region has a profound popular meaning, and (b) that a fresh conception of regional governance is a chance for the implementation of sustainable development. As a provisional conclusion to these reflections, we suggest some guidelines of action for a group of benevolent people looking to implement a more friendly world on the basis of a regional leverage.